Search results for "monacolin K"

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Drug Induced Liver Injury (DILI) due to variability in monacolin K content in Red Yeast Rice (RYR): An expert opinion

2020

Abstract Introduction Red yeast rice (RYR) is an effective cholesterol-lowering nutraceutical reversibly inhibiting 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase. As liver damage is a possible (albeit rare) side effect of HMG-CoA inhibitors, it make sense to focus on the tolerability of the liver to RYR extracts. The aim of this paper is to offer an expert opinion on the risk of liver damage by the use of RYR extract. Methods A review of the available literature has been carried out and critically reviewed by the authors. Results According to a large meta-analysis of 53 randomized clinical trials comprising 112 treatment arms, which included 8535 subjects with 4437 in the RYR arm and …

nutrivigilancesafetyDrugSide effectmedia_common.quotation_subjectliver injury; monacolin K; nutrivigilance; red yeast rice; safety; tolerabilityPharmacologymonacolin K03 medical and health scienceschemistry.chemical_compound0302 clinical medicineNutraceuticalRed yeast rice Liver injury Monacolin K Safety Tolerability NutrivigilanceRed yeast riceMedicinered yeast rice030212 general & internal medicinetolerabilityLiver injury Monacolin K Nutrivigilance Red yeast rice Safety Tolerabilitymedia_commonLiver injurybusiness.industryRyanodine receptormusculoskeletal systemmedicine.disease030205 complementary & alternative medicineCitrininComplementary and alternative medicinechemistryTolerabilitycardiovascular systembusinesstissuesliver injury
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